Practitioner Resources: Scar-Focused

Information Regarding Drug Usage – Links to Abstracts and Research Articles

PracaSil™-Plus

Case Study: Facial Scars PCCA PracaSil™-Plus.

Case Study: Ankle Scars (Old & New) PCCA PracaSil™-Plus.

Case Study: Snake Burn PCCA PracaSil™-Plus Veterinary.

Technical Report: Efficacy of PracaSil™-Plus in Scar Therapy Treatment.

Case Study: Facial Burn & Diaper Rash PCCA PracaSil™-Plus Pediatrics.

Abstract: Compounding for Complex Patients – Pediatrics.

Silicone

Keloids: prevention and management

Comparison of Effectiveness of Silicone Gel Sheeting With Microporous Paper Tape in the Prevention of Hypertrophic Scarring in a Rabbit Model.

Are there any good treatments for keloid scarring after sternotomy.

Effects of combined intralesional 5-Fluorouracil and topical silicone in prevention of keloids: a double blind randomized clinical trial study.

The effects of topically applied silicone gel and its silver derivative on the prevention of hypertrophic scarring in two rabbit ear scarring models.

Promising results from a pilot study on compression treatment of ear keloids.

Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial/subcutaneous tensile reduction sutures and flap surgery for keloid and hypertrophic scar reconstruction.

Management of chest keloids.

Use of silicone gel sheets for prevention of keloid scars after median sternotomy.

A diabetic foot ulcer pilot study: does silicone gel sheeting reduce the incidence of reulceration.

Standard guidelines of care: Keloids and hypertrophic scars.

Positive response of a recurrent keloid scar to topical methyl aminolevulinate-photodynamic therapy.

Phase 2 cross-over multicenter trial on the efficacy and safety of topical cyanoacrylates compared with topical silicone gel in the prevention of pathologic scars.

Medical and surgical management of keloids: a review.

Strategies for prevention of scars: what can we learn from fetal skin.

Acne scars: pathogenesis, classification and treatment.

Experience of silicone gel sheets for patients with keloid scars after median sternotomy.

Topical silicone gel versus placebo in promoting the maturation of burn scars: a randomized controlled trial.

The tensile reduction effects of silicone gel sheeting.

Case series: evaluation of a liquid silicone gel on scar appearance following excisional surgery–a pilot study.

Efficacy of topical cyanoacrylates compared to topical silicone gel in the treatment of hypertrophic scars.

Scar tissue.

Use of Patient and Observer Scar Assessment Scale for evaluation of facial scars treated with self-drying silicone gel.

Aesthetic effect of silicone gel on surgical scars in Asians.

A comparative study evaluating the tolerability and efficacy of two topical therapies for the treatment of keloids and hypertrophic scars.

Occlusion regulates epidermal cytokine production and inhibits scar formation.

A randomized clinical trial to study the effect of silicone gel dressing and pressure therapy on posttraumatic hypertrophic scars.

Silicone-based scar therapy: a review of the literature.

Congenital erosive and vesicular dermatosis with reticulated scarring in a newborn: an innovative treatment using a silicone dressing.

Treatment of hypertrophic scars and keloids with an LBO laser (532 nm) and silicone gel sheeting.

The impact of silicone spray on scar formation. A single-center placebo-controlled double-blind trial.

JAAD online. Over-the-counter scar products for postsurgical patients: disparities between online advertised benefits and evidence regarding efficacy.

Comparison of efficacy of silicone gel, silicone gel sheeting, and topical onion extract including heparin and allantoin for the treatment of postburn hypertrophic scars.

Management of keloids and hypertrophic scars.

The use of silicone gel in the treatment of fresh surgical scars: a randomized study.

The use of pressure and silicone in hypertrophic scar management in burns patients: a pilot randomized controlled trial.

Efficacy of a polyurethane dressing versus a soft silicone sheet on hypertrophic scars.

Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction.

Clinical perspective on silicone dressings and wound management.

Effects of silicone gel on burn scars.

The role of the epidermis in the control of scarring: evidence for mechanism of action for silicone gel.

Morphological analysis of the connective tissue reaction in linear hypertrophic scars treated with intralesional steroid or silicone-gel sheeting. A light and electron microscopic study.

Keloid and hypertrophic scars: a review of recent developments in pathogenesis and management.

An open-label pilot study to evaluate the efficacy and tolerability of a silicone gel in the treatment of hypertrophic scars using clinical and ultrasound assessments.

A comparative clinical study of the treatment of hypertrophic scars with either intralaesional steroid or silicone gel sheeting.

Evolution of silicone therapy and mechanism of action in scar management.

A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management.

The efficacy of topical silicone gel elastomers in the treatment of hypertrophic scars, keloid scars, and post-laser exfoliation erythema.

Current methods of treatment and prevention of pathologic scars.

Nonsurgical management of hypertrophic scars: evidence-based therapies, standard practices, and emerging methods.

A “silicone suture” technique aided to scalp reduction for the treatment of scarring alopecia.

Clinical evaluation of a new self-drying silicone gel in the treatment of scars: a preliminary report.

Topical treatments for hypertrophic scars.

A prospective randomized clinical trial to investigate the effect of silicone gel sheeting (Cica-Care) on post-traumatic hypertrophic scar among the Chinese population.

Non-operative treatment of hypertrophic scars and keloids after burns in children.

Influence of silicone on abnormal scarring.

Audit of reactions to topical silicon used in the management of hypertrophic scars.

Preliminary evaluation of the efficacy of dermatix silicone gel in the reduction of scar elevation and pigmentation.

Evaluation of a self-adherent soft silicone dressing for the treatment of hypertrophic postoperative scars.

Treatment of acne scars with liquid silicone injections: 30-year perspective.

Treatment of keloids and hypertrophic scars.

A randomized, placebo-controlled, double-blind, prospective clinical trial of silicone gel in prevention of hypertrophic scar development in median sternotomy wound.

Silicone occlusive sheeting vs silicone cushion for the treatment of hypertrophic and keloid scars. A prospective-randomized study.

Topical scar modification: hype or help.

The efficacy of magnetic disks for the treatment of earlobe hypertrophic scar.

Hypertrophic and keloidal scars: an approach to polytherapy.

Silastic sheet integrated polymethylmetacrylate splint in addition to surgery for commissure contractures complicated with hypertrophic scar.

International clinical recommendations on scar management.

The effect of silicone gel on basic fibroblast growth factor levels in fibroblast cell culture.

Silicone gel sheets relieve pain and pruritus with clinical improvement of keloid: possible target of mast cells.

Keloid and hypertrophic scars.

Effects of enhanced patient education on compliance with silicone gel sheeting and burn scar outcome: a randomized prospective study.

Silicone sheet for treatment and prevention of hypertrophic scar: a new proposal for the mechanism of efficacy.

Silicone sheeting decreases fibroblast activity and downregulates TGFbeta2 in hypertrophic scar model.

The use of silicone gel for treating children’s burn scars in Saudi Arabia: a case study.

International clinical recommendations on scar management.

Topigel in the treatment of hypertrophic scars after burn injuries.

The effect of silicone gel sheets on perfusion of hypertrophic burn scars.

Biological effects of silicone gel sheeting.

Posttraumatic scar revision: a review and case presentation.

Effect of four treatment variants on the functional and cosmetic state of mature scars.

Silicone occlusive treatment of hypertrophic scar in the rabbit model.

Nonoperative techniques for scar management and revision.

Silicone versus nonsilicone gel dressings: a controlled trial.

Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting.

Silicones in the rehabilitation of burns: a review and overview.

Silicone as a therapeutic aid in the treatment of hypertrophic scars and keloids.

Topical revitalization of body skin.

Silicone gel sheeting.

New innovations in scar management.

The use of silicone gel sheeting in the management of hypertrophic and keloid scars.

Self-adhesive silicone gel sheet: a treatment for hypertrophic scars and keloids.

Silicone thermoplastic sheeting for treatment of facial scars: an improved technique.

Elemental composition changes between breast tissue with and without silicone gel sheeting and hypertrophic scar tissue.

Hypertrophic scars and keloids: which therapeutic options today.

Dynamics of wound healing after silicone device implantation.

Prospective, single-blind, randomized, controlled study to assess the efficacy of the 585-nm flashlamp-pumped pulsed-dye laser and silicone gel sheeting in hypertrophic scar treatment.

Comparison of a silicone gel-filled cushion and silicone gel sheeting for the treatment of hypertrophic or keloid scars.

The use of silicone occlusive sheeting (Sil-K) and silicone occlusive gel (Epiderm) in the prevention of hypertrophic scar formation.

Use of a glycerin-based gel sheeting in scar management.

Static-electric field induction by a silicone cushion for the treatment of hypertrophic and keloid scars.

Silicone gel sheeting for the management of hypertrophic and keloid scars: the mechanism of its action.

Effectiveness of silicone sheets in the prevention of hypertrophic breast scars.

Facial keloids. A 15-year experience.

Cytokine mRNA changes during the treatment of hypertrophic scars with silicone and nonsilicone gel dressings.

Effectiveness of silicone sheets in the prevention of hypertrophic breast scars.

A comparison of Sil-K and Epiderm in scar management.

Silicone cream occlusive dressing–a novel noninvasive regimen in the treatment of keloid.

Silicone gel sheeting for the prevention and management of evolving hypertrophic and keloid scars.

Topical silastic gel sheeting for treating and controlling hypertrophic and keloid scars: case study.

Symptomatic keloids in two children. Dramatic improvement with silicone cream occlusive dressing.

Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids.

Silicone gel sheeting in scar therapy.

Evaluation of silicone-gel sheeting on early wound healing of linear incisions.

Cica-Care gel sheeting in the management of hypertrophic scarring.

Silicone gel treatment of extensive hypertrophic scarring following toxic epidermal necrolysis.

Silicone use in keloids.

A controlled clinical trial of topical silicone gel sheeting in the treatment of hypertrophic scars and keloids.

Treatment of hypertrophic and keloid scars with SILASTIC Gel Sheeting.

Experience with silastic gel sheeting in pediatric scarring.

Sense and nonsense of scar creams and gels.

Topical silicone gel sheeting in the treatment of hypertrophic scars and keloids. A dermatologic experience.

Silicone gel in the treatment of burn and prevention of hypertrophic scar.

Hypertrophic sternal scars: silicone gel sheet versus Kenalog injection treatment.

Beneficial effects of silicone cream on grafted skin.

The effect of sodium-hyaluronate on scar tissue formation under a subconjunctival silicone implant in the rabbit.

Topical silicone gel for the prevention and treatment of hypertrophic scar.

Treatment of scars and keloids with a cream containing silicone oil.

Why does topical silicone gel improve hypertrophic scars? A hypothesis.

Silicone gel in the treatment of keloids.

Topical silicone gel: a new treatment for hypertrophic scars.

Silicone gel appears inexplicably to flatten, lighten hypertrophic scars from burns.

Silicone gel in the treatment of keloid scars.

Silicone gel sheet tie-over for skin graft on the eyelid following release of scar contracture.

Effectiveness of silastic sheet coverage in the treatment of scar keloid (hypertrophic scar).

Silicone gel in scar treatment.

The use of plastic face mask and silicone gloves and boots as alternative to compression suits for treating hypertrophic scars.

Silicone gel: a new treatment for burn scars and contractures.

Flatten that scar.

Closed capsulotomy causing fractures of the scar capsule and the silicone bag of a breast implant. Case report.

Treatment of painful scars on soles and digits with injections of fluid silicone.

Liquid silicone injections to improve scars: is this a solution to the problem.

Silicone fluid and steroids in the prevention of adhesions.

SCARprin Review.

Dermatix: Does Dermatix Work

Talsyn CI: Does Talsyn CI Work.

Kelo-Cote: Does Kelo-Cote Work.

Prefer On: Does Prefer On Work.

Scar Esthetique: Does Scar Esthetique Work.

Scar Zone: Does Scar Zone Work.

Scar Fade: Does Scar Fade Work.

Cimeosil: Does Cimeosil Work.

Spenco 2nd Skin Scar Gel: Does Spenco 2nd Skin Scar Gel Work.

Silicone Scar Treatment| My Experience with Silicone for Scars.

Clinical Trials, Papers and Studies Involving the Effectiveness of Silicone Gel in Managing Scars.

Silicone – Stretch Marks

How to get Rid of Stretch Marks After Working Out.

Does Mederma Really Work for Stretch Marks.

Scars and Stretch Marks.

Creams to Remove Stretch Marks.

Stretch Mark Treatment.

How to Eliminate Stretch Marks & Scars.

Topical revitalization of body skin.

General Corticosteroids

Treatment of eosinophilic esophagitis with inhaled corticosteroids.

Topical corticosteroids applied with a squirt system are more effective than a nasal spray for steroid-dependent olfactory impairment.

Pressure-pulsed inhalation corticosteroid therapy in olfactory disorders: how we do it.

Are there any good treatments for keloid scarring after sternotomy

Clinical applications of basic research that shows reducing skin tension could prevent and treat abnormal scarring: the importance of fascial/subcutaneous tensile reduction sutures and flap surgery for keloid and hypertrophic scar reconstruction

Hypertrophic scar in a dog: histological and clinical features

595nm pulsed dye laser combined with intralesional corticosteroids in hypertrophic symptomatic scars following breast reduction surgery

Standard guidelines of care: Keloids and hypertrophic scars

Management of hypertrophic scars and keloids

Phase 2 cross-over multicenter trial on the efficacy and safety of topical cyanoacrylates compared with topical silicone gel in the prevention of pathologic scars

The cost effectiveness of intralesional steroid therapy for keloids

The effect of combined steroid and calcium channel blocker injection on human hypertrophic scars in animal model: a new strategy for the treatment of hypertrophic scars

Medical and surgical management of keloids: a review

Perioperative conditions affect long-term hypertrophic scar formation

Surgical excision and immediate postoperative radiotherapy versus cryotherapy and intralesional steroids in the management of keloids: a prospective clinical trial

Scar tissue

A comparative study evaluating the tolerability and efficacy of two topical therapies for the treatment of keloids and hypertrophic scars

Letter: further options for treatment of hypertrophic scars and keloids

The role of full-thickness skin grafting and steroid injection in the treatment of auricular keloids

The most current algorithms for the treatment and prevention of hypertrophic scars and keloids

A review of the effectiveness of antimitotic drug injections for hypertrophic scars and keloids

Auricular keloids: treatment and results

Management of keloids and hypertrophic scars

Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids

Successful treatment of earlobe keloids in the pediatric population

Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars

An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids

Comparison of intralesional verapamil with intralesional triamcinolone in the treatment of hypertrophic scars and keloids

Evaluating the tolerability and efficacy of etanercept compared to triamcinolone acetonide for the intralesional treatment of keloids

Morphological analysis of the connective tissue reaction in linear hypertrophic scars treated with intralesional steroid or silicone-gel sheeting. A light and electron microscopic study

The use of corticosteroids to treat keloids: a review

Poiseuille’s law and large-bore needles: insights into the delivery of corticosteroid injections in the treatment of keloids

Effects of interferon-alpha2b on keloid treatment with triamcinolone acetonide intralesional injection

Treatment of postdermabrasion facial hypertrophic and keloid scars with intralesional 5-Fluorouracil injections

Role of liquid nitrogen alone compared with combination of liquid nitrogen and intralesional triamcinolone acetonide in treatment of small keloids

A comparative clinical study of the treatment of hypertrophic scars with either intralaesional steroid or silicone gel sheeting

A review of the biologic effects, clinical efficacy, and safety of silicone elastomer sheeting for hypertrophic and keloid scar treatment and management

Current methods of treatment and prevention of pathologic scars

Head and neck keloid: treatment by core excision and delayed intralesional injection of steroid

Current use of steroids in management of abnormal raised skin scars

Betamethasone cream for the treatment of pre-pubertal labial adhesions

New combination of triamcinolone, 5-Fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars

Safety and efficacy of local administration of contractubex to hypertrophic scars in comparison to corticosteroid treatment. Results of a multicenter, comparative epidemiological cohort study in Germany

Combined therapy in the treatment of auricular keloids

New technique for injecting corticosteroid in keloids scarring

Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients

Keloid pathogenesis and treatment

Treatment of keloids and hypertrophic scars

An open label study of clobetasol propionate 0.05% and betamethasone valerate 0.12% foams in the treatment of mild to moderate acne keloidalis

Hypertrophic and keloidal scars: an approach to polytherapy

The effects of mitomycin C and 5-fluorouracil/triamcinolone on fibrosis/scar tissue formation secondary to subglottic trauma (experimental study)

Successful management of vulvar adhesions with potent topical corticosteroids: a case report

Medical and surgical therapies for keloids.

Intralesional 5-fluorouracil in the treatment of keloid scars

Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring

Hypertrophic scars and keloids: etiology and management

Laser scar revision: comparison study of 585-nm pulsed dye laser with and without intralesional corticosteroids

A comparison of the combined effect of cryotherapy and corticosteroid injections versus corticosteroids and cryotherapy alone on keloids: a controlled study

Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments

Treatment of scars by steroid injections

Nonoperative techniques for scar management and revision

Scar contractures, hypertrophic scars, and keloids

Experience with difficult keloids

Treatment of keloid scars with pulsed dye laser and intralesional steroid

Keloids and hypertrophic scars: results with intraoperative and serial postoperative corticosteroid injection therapy

Treatment of inflamed hypertrophic scars using intralesional 5-FU

The treatment of hypertrophic scars and keloids

Hypertrophic scars and keloids

Acute and chronic animal models for excessive dermal scarring: quantitative studies

Aetiology and management of hypertrophic scars and keloids

Effect of injection of triamcinolone on type 1 procollagen and fibronectin in scar tissue

Prevention of earlobe keloid recurrence with postoperative corticosteroid injections versus radiation therapy: a randomized, prospective study and review of the literature

Treatment of hypertrophic and keloid scars

A comparison of intralesional triamcinolone and cryosurgery in the treatment of acne keloids

Treatment of keloids and hypertrophic scars. Pilot study with intralesional Lipotalon injections

Keloids and hypertrophic scars

Scars and keloids

Intra- and postoperative steroid injections for keloids and hypertrophic scars

Topical corticosteroids. Which drug and when

Cortisone jet injection as therapy of hypertrophic scars and keloids

Treatment methods of keloid and hypertrophic scar formation

Evaluation of the effect of topical steroids on human scar contracture using a nude mouse model

Treatment of keloids by single intraoperative perilesional injection of repository steroid

Conservative therapy of scars and wrinkles

A protocol for the treatment of hypertrophic scars and keloids

Clinico-pathological evaluation of keloids treated with intralesional injections of corticoid

Prevention of hypertrophic scarring

Dose-dependent effects of short-term methylprednisolone on myocardial infarct extent, scar formation, and ventricular function

Treatment of keloid scars by combined cryosurgery and intralesional corticosteroids

Facial keloids and their management

The valve of prednisone in the prevention of scarring after vasovasostomy

Betamethasone in the treatment of hypertrophic scars

Combined modalities in the management of hypertrophic scars and keloids

The combined use of cryosurgery and intralesional injections of suspensions of fluorinated adrenocorticosteroids for reducing keloids and hypertrophic scars

Treatment of keloids and some skin diseases with topical injections of triamcinolone

The place of intralesional steroid therapy in dermatology

Healing of surgical wounds of the skin of rats after topical application of hydrocortisone, prednisolone and triamcinolone in identical concentrations and associated with an antibiotic

Treatment of cheloids and cheloid scars with intralesional corticoid injections

Use of corticoids in local treatment of hypertrophic scars and keloids in children

Silicone fluid and steroids in the prevention of adhesions

The action of fluocinolone acetonide upon scar tissue formation

The treatment of keloids and hypertrophic scars by corticosteroids

Pharmacodynamic effect of a preparation of cartilage on scar formation in normal experimental wounds and in scar formation delayed by cortisone

Decreased scar formation with topical corticosteroid treatment

The treatment of hyposmia with intranasal steroids.

General Corticosteroids – Stretch Marks

Aldosterone and mineralocorticoid receptor antagonists modulate elastin and collagen deposition in human skin

Ulceration of Striae distensae in high-grade glioma patients on concurrent systemic corticosteroid and bevacizumab therapy

Elastotic striae associated with striae distensae after application of very potent topical corticosteroids

Treatment outcome using prednisone in corticosteroid-responsive primary nephrotic syndrome in children

Cosmetic use of skin depigmentation products in Africa

Extensive striae distensae as a result of topical corticosteroid therapy in psoriasis vulgaris

A case of edematous striae distensae in lupus nephritis

Effects of mometasone furoate on human keratinocytes and fibroblasts in vitro

Loratadine

How to Treat Raised Scars Under the Eyelash Line.

Montelukast

The efficacy and tolerability of inhaled montelukast plus inhaled mometasone compared with mometasone alone in patients with chronic asthma.

A phase I randomized, placebo-controlled, dose-exploration study of single-dose inhaled montelukast in patients with chronic asthma.

Inhaled montelukast inhibits cysteinyl-leukotriene-induced bronchoconstriction in ovalbumin-sensitized guinea-pigs: the potential as a new asthma medication.

Betamethasone

Local steroid treatment of allergic diseases of the upper respiratory tract.

Structure-activity relationships of topically active steroids: the selection of fluticasone propionate.

Other anti-inflammatory uses of intranasal corticosteroids in upper respiratory inflammatory diseases.

Fluticasone

The effect of intranasal fluticasone propionate irrigations on salivary cortisol, intraocular pressure, and posterior subcapsular cataracts in postsurgical chronic rhinosinusitis patients.

A randomized double-blind study to compare the effects of nasal fluticasone and betamethasone on the hypothalamo-pituitary-adrenal axis and bone turnover in patients with nasal polyposis.

Fluticasone furoate nasal spray in the treatment of allergic rhinitis.

The effect of topical fluticasone on nasal nitric oxide levels in a patient with allergic rhinitis.

Episodic viral wheeze in preschool children: effect of topical nasal corticosteroid prophylaxis.

The pharmacological basis for the treatment of perennial allergic rhinitis and non-allergic rhinitis with topical corticosteroids.

Randomized trial of inhaled fluticasone propionate in chronic stable pulmonary sarcoidosis: a pilot study.

Pruritic urticarial papules and plaques of pregnancy wholly abated with one week twice daily application of fluticasone propionate lotion: A case report and review of the literature

Fluticasone (Flonase®).

Fluticasone topical (Rx).

Fluticasone Propionate.

Other anti-inflammatory uses of intranasal corticosteroids in upper respiratory inflammatory diseases.